Isle of Palms South Rentals
- Click For Pricing
Expedia
Dockside: Boat dock, Heated Pool, Close to Beach
- Bedrooms:
- 3
- Bathrooms:
- 4
- Sleeps:
- 8
Beautifully remodeled home with your very own boat lift and dock; making it easy to enjoy boating and water sports anyti ...
Click For PricingExpedia
- From $324 per night (USD)
VRBO
Beachy Bungalow: 3BR Home w\/ Billiards\/grill!
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 8
This cozy 1-story, 3 bedroom home is the perfect place to relax and enjoy all that Jacksonville has to offer. Located in ...
From $324 per night (USD)VRBO
- From $350 per night (USD)
VRBO
Intracoastal Views- 10 mins to Beach\/Mayo Clinic
- Bedrooms:
- 2
- Bathrooms:
- 5
- Sleeps:
- 12
Located on the intracoastal, overlooking the Florida marsh you won't find a more tranquil spot. Sway in the hammock chai ...
From $350 per night (USD)VRBO
- From $210 per night (USD)
Expedia
Luxury Home 2 miles from Mayo
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 6
This is a beach modern style home. Located in a quiet neighborhood off the main street close to the beach (3.5miles) and ...
From $210 per night (USD)Expedia
- From $323 per night (USD)
VRBO
Big Wheelchair Accessible Home Close to Beach\/Mayo with Zen Den and Fenced Yard
- Bedrooms:
- 3
- Bathrooms:
- 4
- Sleeps:
- 10
*New to VRBO* Welcome to “The Cottage” a recently remodeled spacious and accessible brick ranch home in the heart of Ja ...
From $323 per night (USD)VRBO
- Click For Pricing
Expedia
Waterfront Jacksonville Retreat w\/ Boat Dock!
- Bedrooms:
- 3
- Bathrooms:
- 4
- Sleeps:
- 8
Located in the vibrant city of Jacksonville, this 4-bedroom, 3-bath vacation rental is the ideal base for exploring all ...
Click For PricingExpedia
- From $282 per night (USD)
VRBO
Lux Pool Home Close to Mayo & Jacksonville Beach!
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 6
This freshly remodeled open concept, pool home, close to Mayo Clinic and Jax beach is sure to wow you! The home includes ...
From $282 per night (USD)VRBO
- From $191 per night (USD)
VRBO
Pablo Pointe- Single Family Home directly across from the Mayo Clinic
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 6
Fully renovated family ranch home. Ideal for families and/or patients visiting the Mayo Clinic. The entire group will en ...
From $191 per night (USD)VRBO
- From $157 per night (USD)
VRBO
5 STAR Upscale King Suite 1 Min to Mayo Clinic!
- Bedrooms:
- 2
- Bathrooms:
- 2
- Sleeps:
- 4
Beautiful "NEW" Gated Suite near MAYO CLINIC! Elevator included. Brand new construction! Designer furnished. Spacious Su ...
From $157 per night (USD)VRBO
- From $147 per night (USD)
Expedia
Amazing New MAYO King Suite
- Bedrooms:
- 2
- Bathrooms:
- 1
- Sleeps:
- 3
Beautiful "NEW" Gated Suite near MAYO CLINIC! Elevator included. Brand new construction! Designer furnished. Spacious Su ...
From $147 per night (USD)Expedia
- From $188 per night (USD)
VRBO
Minutes away from Mayo Clinic, jax Beach, UNF, Ponte Vedra Beach, and PGA & TPC.
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 6
Fully-Furnished 3 bedroom 2 bathroom, quite neighborhood, higher ceiling in the living area. Little storage in the back ...
From $188 per night (USD)VRBO
- From $180 per night (USD)
Expedia
The Retreat close to Mayo Clinic!
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 6
Book with confidence with an experienced host! The Retreat is a fully renovated 3 bedroom/2 bathroom house. Guests are ...
From $180 per night (USD)Expedia
- From $251 per night (USD)
VRBO
Mayo Clinic townhouse in San Pablo with Primary suite located on the 1st floor
- Bedrooms:
- 3
- Bathrooms:
- 3
- Sleeps:
- 6
Beautiful townhouse located in the sought after San Pablo area. Fully furnished 3 bedroom, 2.5 bathrooms and 2 car garag ...
From $251 per night (USD)VRBO
- From $446 per night (USD)
Expedia
Marsh View: Renovated close to Mayo! Heated Pool
- Bedrooms:
- 2
- Bathrooms:
- 4
- Sleeps:
- 10
Marsh View is a 4 bedroom 2 bathroom, pet friendly home on a spacious lot with amazing views of the intracoastal waterwa ...
From $446 per night (USD)Expedia
- From $316 per night (USD)
VRBO
3\/2 Home, Heated Pool, 1mi to Mayo, 3mi to Beach
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 8
Just listed!! 3 bedroom 2 bath pool home. Only 1 mile from Mayo and 3 miles from Jacksonville Beach. The home is all one ...
From $316 per night (USD)VRBO
- From $299 per night (USD)
Expedia
Modern Townhouse minutes from Mayo Clinic UNF & Beach
- Bedrooms:
- 3
- Bathrooms:
- 3
- Sleeps:
- 9
Beautiful townhouse located in the sought after San Pablo area. Fully furnished 3 Bedroom, 2.5 bathroom & car garage. Th ...
From $299 per night (USD)Expedia
- From $2000 per night (USD)
VRBO
HCB 53 Suenos Luxury Yacht
- Bedrooms:
- 1
- Bathrooms:
- 1
- Sleeps:
- 2
Want to ride to the sandbar in Style? Fort George, Bird Island, Matanzas Inlet in St. Augustine? This is a NÉW 53 foot ...
From $2000 per night (USD)VRBO
- From $186 per night (USD)
Expedia
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
- Bedrooms:
- 3
- Bathrooms:
- 4
- Sleeps:
- 8
We believe that you will feel right at home in our bungalow. The backyard will feel like an oasis with a comfortable con ...
From $186 per night (USD)Expedia
- From $500 per night (USD)
VRBO
Spacious & Private 5 Bed Bungalow Close to Beaches & Mayo Clinic!
- Bedrooms:
- 3
- Bathrooms:
- 5
- Sleeps:
- 7
THIS LISTING INCLUDES THE FULL HOUSE WITH TWO FULL KITCHENS & LAUNDRY ROOMS. ALSO A FULL SEPARATE MASTER SUITE. Relax ...
From $500 per night (USD)VRBO
- From $100 per night (USD)
VRBO
Spacious 1 King Bed Suite Nearby Beach and Mayo Clinic
- Bedrooms:
- 1
- Bathrooms:
- 1
- Sleeps:
- 2
Enjoy a private suite complete with kitchenette, laundry, large closet, and bath with tub. Stay on your own or bring a g ...
From $100 per night (USD)VRBO
- Click For Pricing
Expedia
The Suite Beach Dream
- Bedrooms:
- 2
- Bathrooms:
- 2
- Sleeps:
- 3
Welcome to the Sunshine City! We are minutes away from Jacksonville Beach. 7 minute drive from the beach and close to s ...
Click For PricingExpedia
- From $350 per night (USD)
Expedia
Fancy private pool home in Jax beach
- Bedrooms:
- 2
- Bathrooms:
- 4
- Sleeps:
- 10
Have fun with the whole family at this stylish place. This house offers a relaxing feel for family and friends vacation ...
From $350 per night (USD)Expedia
- From $275 per night (USD)
VRBO
Large Marsh View Home - Near Mayo Clinic and Beaches
- Bedrooms:
- 3
- Bathrooms:
- 4
- Sleeps:
- 10
**NEW TO VRBO** Beautiful, marsh view home that was recently remodeled with many luxury amenities. The home is fully fur ...
From $275 per night (USD)VRBO
- From $90 per night (USD)
VRBO
The Petite Retreat - Walk to Mayo Clinic!
- Bedrooms:
- 1
- Bathrooms:
- 1
- Sleeps:
- 2
The Petite Retreat is fully renovated. This cozy studio/In-law suite features: +king bed +ensuite bathroom +full siz ...
From $90 per night (USD)VRBO
- From $324 per night (USD)
VRBO
Mayo Clinc 1mile from Intercoastal waterfront home w\/pool and Breathtaking Views
- Bedrooms:
- 3
- Bathrooms:
- 3
- Sleeps:
- 8
Enjoy amazing water views from EVERY single room in this newly renovated ICW pool home (renovated in March 2016 / Pool N ...
From $324 per night (USD)VRBO
- From $201 per night (USD)
Expedia
Cozy home near Intracoastal Waterway with screened porch, washer\/dryer & AC
- Bedrooms:
- 2
- Bathrooms:
- 2
- Sleeps:
- 4
Jacksonville's Charm Our calendar is updated in real-time & our nightly rates are accurately displayed. Simply enter yo ...
From $201 per night (USD)Expedia
- From $161 per night (USD)
VRBO
This house is a 3 bedroom(s), 2 bathrooms, located in Jacksonville, FL.
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 6
Fabulous beach blvd townhome- with backyard sun room, fire pit, pool table, dart board- something for the whole family! ...
From $161 per night (USD)VRBO
- From $177 per night (USD)
Expedia
Fun 5 Star Hot Tub\/Beaches getaway Near MAYO!
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 6
Private quiet 3 Bedroom Home 1300 Sq. Ft. Dedicated workspace and fast WIFI. 3 TVs with Netflix, Hulu, ROKU. Just 5 min ...
From $177 per night (USD)Expedia
- From $148 per night (USD)
VRBO
Cozy Home Near Mayo & Beaches. Dog-friendly!
- Bedrooms:
- 2
- Bathrooms:
- 2
- Sleeps:
- 4
Private home located in the heart of Jacksonville and close to everything! Centrally located off Beach Blvd, there are e ...
From $148 per night (USD)VRBO
- From $200 per night (USD)
Expedia
Beautiful Coastal Home near Mayo Clinic. Pet Friendly!
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 6
Come and relax at this impeccably clean and cozy coastal home less than 3 minutes from the Mayo Clinic Jacksonville, 7 m ...
From $200 per night (USD)Expedia
- From $180 per night (USD)
VRBO
The Lily House- Flexible Lease Terms, Hospitals and Beaches
- Bedrooms:
- 3
- Bathrooms:
- 3
- Sleeps:
- 8
Come enjoy the sunshine state and plenty of natural light throughout this brand new, fully furnished townhome- minutes t ...
From $180 per night (USD)VRBO
- From $118 per night (USD)
Expedia
Brockway · Cozy JAX Beach Home: Close to Beach\/Mayo\/UNF
- Bedrooms:
- 1
- Bathrooms:
- 2
- Sleeps:
- 4
Summary: Entire cozy, relaxing, and peaceful home. Queen bed in the master bedroom and expandable queen daybed in the gu ...
From $118 per night (USD)Expedia
- From $180 per night (USD)
VRBO
The Coastal Blues
- Bedrooms:
- 2
- Bathrooms:
- 2
- Sleeps:
- 4
With these summer heats, come cool off at our unit! We are minutes away from Jacksonville Beach. 7 minute drive from th ...
From $180 per night (USD)VRBO
- Click For Pricing
Expedia
Short or Mid term rental, Private pool, minutes to Mayo\/Baptist Hospital
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 6
Single story home located near Mayo Clinic and also 10 minutes drive to the beach. This home has been available for ren ...
Click For PricingExpedia
- From $402 per night (USD)
VRBO
Single level heated pool 5 mins to beach by Mayo
- Bedrooms:
- 2
- Bathrooms:
- 4
- Sleeps:
- 8
Relax, recharge and enjoy the tranquility at Osprey's Rest! Huge backyard with private heated pool, grill area and a var ...
From $402 per night (USD)VRBO
- From $279 per night (USD)
Expedia
Mayo Clinic 1.8 miles #2 Your Home Away From Home
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 5
This 3 /2 is located in the quiet neighborhood of Isle of Palms. It has been fully remodeled inside and out. Extra cle ...
From $279 per night (USD)Expedia
- Click For Pricing
VRBO
5 bedroom home with heated pool and hot tub
- Bedrooms:
- 4
- Bathrooms:
- 5
- Sleeps:
- 10
Beautiful 5 bedroom home with four baths. Heated pool and hot tub with jets enclosed with a cage. Outdoor fireplace and ...
Click For PricingVRBO
- From $498 per night (USD)
Expedia
Intracoastal Pool Retreat near Beaches+Mayo Clinic
- Bedrooms:
- 2
- Bathrooms:
- 5
- Sleeps:
- 12
Forget your worries in this spacious and serene space. Located in the Isle of Palms community in Jacksonville this 4 bed ...
From $498 per night (USD)Expedia
- From $338 per night (USD)
VRBO
14543 Luth Drive · The Palms Retreat~Firepit~Fenced Yard~Pet Friendly
- Bedrooms:
- 3
- Bathrooms:
- 4
- Sleeps:
- 10
Coastal dreams come to life at our home away from home. Florida sunshine pours in the spacious, open living/dining area ...
From $338 per night (USD)VRBO
- Click For Pricing
Expedia
PARADISE Home with Private Pool.
- Bedrooms:
- 4
- Bathrooms:
- 4
- Sleeps:
- 8
Your family will be enjoying with beautiful home, private pool, lightning up backyard, Paradise swing . Minute to the be ...
Click For PricingExpedia
- From $250 per night (USD)
VRBO
Spacious 4 Bed Bungalow Close to Mayo & Beaches
- Bedrooms:
- 2
- Bathrooms:
- 4
- Sleeps:
- 8
Relax and unwind in a beachy-style bungalow with a short 8-minute drive to the ocean! Nearby to Mayo Clinic and local re ...
From $250 per night (USD)VRBO
- From $224 per night (USD)
VRBO
New Townhome Lake View, Minutes to Mayo & Beaches
- Bedrooms:
- 3
- Bathrooms:
- 3
- Sleeps:
- 8
Just Listed! New Built Townhouse with Lake View in a gated community. 3 bedroom, 2.5 bathrooms with 2 car garage. Master ...
From $224 per night (USD)VRBO
- From $180 per night (USD)
VRBO
LUXURY HOME FOR TRAVELING MAYO PATIENTS\/EXECUTIVE BUSINESS & FL LIVING VISIT
- Bedrooms:
- 2
- Bathrooms:
- 1
- Sleeps:
- 2
Our LUXURY HOME is open to executive business travelers, FL living visit and Mayo traveling patients. We provide you all ...
From $180 per night (USD)VRBO
- From $325 per night (USD)
Expedia
Intercoastal waterfront home w\/pool & Breathtaking Views 1mile from Mayo Clinc
- Bedrooms:
- 3
- Bathrooms:
- 3
- Sleeps:
- 8
Enjoy amazing water views from EVERY room in this renovated ICW pool home. Fully furnished 3 bedroom, 2.5 bath (1/2 bath ...
From $325 per night (USD)Expedia
- From $130 per night (USD)
VRBO
Private in-law suite with full kitchen, washer\/dryer, & central AC
- Bedrooms:
- 1
- Bathrooms:
- 2
- Sleeps:
- 4
By the Beach - In-Law Suite Our calendar is updated in real-time & our nightly rates are accurately displayed. Simply e ...
From $130 per night (USD)VRBO
- From $153 per night (USD)
Expedia
Quiet home on a cul-de-sac with screened patio, W\/D, & central AC
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 6
By the Beach - Main Our calendar is updated in real-time & our nightly rates are accurately displayed. Simply enter you ...
From $153 per night (USD)Expedia
- From $294 per night (USD)
VRBO
Renovated home + in-law suite near the beach with patio, 2 kitchens, AC, & W\/Ds
- Bedrooms:
- 3
- Bathrooms:
- 5
- Sleeps:
- 10
By the Beach - Full Property Our calendar is updated in real-time & our nightly rates are accurately displayed. Simply ...
From $294 per night (USD)VRBO
- Click For Pricing
Expedia
Impeccable Luxury Suite -3Tvs-1 Min to Mayo Clinic
- Bedrooms:
- 2
- Bathrooms:
- 2
- Sleeps:
- 4
Beautiful "NEW" Gated Suite near MAYO CLINIC! Elevator included. Brand new construction! Designer furnished. Spacious Su ...
Click For PricingExpedia
- From $130 per night (USD)
VRBO
Cedar's Apartment. 1 bed, 2 bath
- Bedrooms:
- 2
- Bathrooms:
- 1
- Sleeps:
- 5
Welcome to our charming apartment in the San Pablo area close to Jacksonville Beach. Ideal for medical professionals or ...
From $130 per night (USD)VRBO
- From $130 per night (USD)
Expedia
Siesta's Apartment. 1 bed, 2 bath
- Bedrooms:
- 2
- Bathrooms:
- 1
- Sleeps:
- 5
Just 2 min away from Mayo Clinic and 5 min away from Beaches! Welcome to our charming apartment in the San Pablo area c ...
From $130 per night (USD)Expedia
- From $784 per night (USD)
VRBO
Waterfront Oasis - 5 bedrooms, private pool and 2 docks
- Bedrooms:
- 5
- Bathrooms:
- 5
- Sleeps:
- 10
Discover the epitome of luxury living at the "Chateau Coquina"—a haven that seamlessly combines opulence with the allure ...
From $784 per night (USD)VRBO
- From $212 per night (USD)
Expedia
Tres Palmas!Renovated Pool Home Near Mayo & Beach!
- Bedrooms:
- 2
- Bathrooms:
- 4
- Sleeps:
- 6
Comfort, location, and calm! From the moment you arrive at Las Palmas you will feel that the home has been designed with ...
From $212 per night (USD)Expedia
- From $194 per night (USD)
VRBO
NEW- The Cove at San Pablo- Across from the Mayo Clinic
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 6
**NEW** Welcome to the Cove at San Pablo! Come visit Jax and relax in our newly renovated and fully furnished with 3 bed ...
From $194 per night (USD)VRBO
- From $269 per night (USD)
VRBO
Manatee House: Private Marsh View Retreat - 1 Mile to Mayo, 5 Miles to Beaches
- Bedrooms:
- 3
- Bathrooms:
- 4
- Sleeps:
- 12
You will love this beautiful and comfortable large marsh view home. Perfect location in a quiet neighborhood within walk ...
From $269 per night (USD)VRBO
- From $130 per night (USD)
VRBO
Seaside Oasis ~ Jacksonville Beach
- Bedrooms:
- 2
- Bathrooms:
- 2
- Sleeps:
- 6
Seaside Oasis is a beachside 2 bedroom and 2 bathroom unit in Jacksonville Beach. ONLY a 7 minute drive from the beach a ...
From $130 per night (USD)VRBO