Isle of Palms, Florida Vacation Rentals. Book Beach Rentals, Lake Houses, Condos, Cabins, Villas, and Homes in Isle of Palms, Florida on RentalSaver.com!

Isle of Palms Rentals

From $321 per night (USD)
VRBO
Mayo Clinic townhouse in San Pablo with Primary suite located on the 1st floor
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Beautiful townhouse located in the sought after San Pablo area. Fully furnished 3 bedroom, 2.5 bathrooms and 2 car garag ...
From $321 per night (USD)
VRBO
From $343 per night (USD)
Expedia
Comfy Mayo Retreat; Heated Pool, Close to Beach
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
Palms Bungalow is a 3 bedroom 2 bath pool home, only 1 mile from Mayo Clinic and 3 miles from Jacksonville Beach. This o ...
From $343 per night (USD)
Expedia
From $350 per night (USD)
VRBO
Modern Townhouse minutes from Mayo Clinic UNF & Beach
Bedrooms:
2
Bathrooms:
3
Sleeps:
9
Beautiful townhouse located in the sought after San Pablo area. Fully furnished 3 Bedroom, 2.5 bathroom & car garage. Th ...
From $350 per night (USD)
VRBO
From $2483 per night (USD)
Expedia
HCB 53 Suenos Luxury Yacht
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
Want to ride to the sandbar in Style? Fort George, Bird Island, Matanzas Inlet in St. Augustine? This is a NÉW 53 foot ...
From $2483 per night (USD)
Expedia
From $252 per night (USD)
VRBO
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
Bedrooms:
3
Bathrooms:
4
Sleeps:
8
We believe that you will feel right at home in our bungalow. The backyard will feel like an oasis with a comfortable con ...
From $252 per night (USD)
VRBO
From $368 per night (USD)
Expedia
Your Home Away From Home and 2 miles from The Mayo Clinic and Snowbirds welcomed
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
3 bedroom 2 bath home newly renovated located in a quiet neighborhood 2 miles from Mayo Clinic and a few minutes from th ...
From $368 per night (USD)
Expedia
From $264 per night (USD)
VRBO
New Townhome Lake View, Minutes to Mayo & Beaches
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
Just Listed! New Built Townhouse with Lake View in a gated community. 3 bedroom, 2.5 bathrooms with 2 car garage. Master ...
From $264 per night (USD)
VRBO
From $374 per night (USD)
Expedia
Mayo Clinc 1mile from Intercoastal waterfront home w/pool and Breathtaking Views
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
Enjoy amazing water views from EVERY single room in this newly renovated ICW pool home (renovated in March 2016 / Pool N ...
From $374 per night (USD)
Expedia
From $528 per night (USD)
VRBO
Pool & Hot Tub Home w/ Game Room! 1 Mile to Beach!
Bedrooms:
3
Bathrooms:
4
Sleeps:
10
This house was thoughtfully put together with large groups in mind. Perfect for entire families, friends vacations, or j ...
From $528 per night (USD)
VRBO
From $348 per night (USD)
Expedia
Lux Pool Home Close to Mayo & Jacksonville Beach!
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
This freshly remodeled open concept, pool home, close to Mayo Clinic and Jax beach is sure to wow you! The home includes ...
From $348 per night (USD)
Expedia
From $328 per night (USD)
VRBO
Fancy private pool home in Jax beach
Bedrooms:
2
Bathrooms:
4
Sleeps:
10
Have fun with the whole family at this stylish place. This house offers a relaxing feel for family and friends vacation ...
From $328 per night (USD)
VRBO
From $400 per night (USD)
Expedia
Tranquility by Mayo w/ Heated Pool Mins to Beach
Bedrooms:
2
Bathrooms:
4
Sleeps:
8
Experience tranquility at Osprey’s Rest, a pet-friendly beach house in Jacksonville Beach’s serene Isle of Palms neighbo ...
From $400 per night (USD)
Expedia
From $604 per night (USD)
VRBO
Roomy Getaway | Heated Pool, Walk to Marina
Bedrooms:
3
Bathrooms:
5
Sleeps:
12
Welcome to The Sand Castle - 2,423 square feet of comfort, perfect for families or groups of up to 12. With two separat ...
From $604 per night (USD)
VRBO
From $269 per night (USD)
Expedia
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
Bedrooms:
3
Bathrooms:
4
Sleeps:
10
*New to VRBO* Welcome to “The Cottage” a recently remodeled spacious and accessible brick ranch home in the heart of Ja ...
From $269 per night (USD)
Expedia
From $368 per night (USD)
VRBO
Mayo Clinic 1.8 miles #2 Your Home Away From Home
Bedrooms:
2
Bathrooms:
3
Sleeps:
5
This 3 /2 is located in the quiet neighborhood of Isle of Palms. It has been fully remodeled inside and out. Extra cle ...
From $368 per night (USD)
VRBO
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Expedia
5 bedroom home with heated pool and hot tub
Bedrooms:
4
Bathrooms:
5
Sleeps:
10
Beautiful 5 bedroom home with four baths. Heated pool and hot tub with jets enclosed with a cage. Outdoor fireplace and ...
Click For Pricing
Expedia
From $1016 per night (USD)
VRBO
Summer Breeze - Heated Pool - 4 min to Mayo
Bedrooms:
2
Bathrooms:
4
Sleeps:
10
Summer Breeze -Heated Pool - 4 min to Mayo Welcome to Summer Breeze! Newly remodeled and spacious home sits on 1/3 acre ...
From $1016 per night (USD)
VRBO
From $207 per night (USD)
VRBO
The Lily House- Flexible Lease Terms, Hospitals and Beaches
Bedrooms:
3
Bathrooms:
3
Sleeps:
8
Come enjoy the sunshine state and plenty of natural light throughout this brand new, fully furnished townhome- minutes t ...
From $207 per night (USD)
VRBO
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VRBO
Waterfront Jacksonville Retreat w/ Boat Dock!
Bedrooms:
3
Bathrooms:
4
Sleeps:
8
Located in the vibrant city of Jacksonville, this 4-bedroom, 3-bath vacation rental is the ideal base for exploring all ...
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VRBO
From $182 per night (USD)
Expedia
Amazing New MAYO King Suite
Bedrooms:
1
Bathrooms:
1
Sleeps:
3
Beautiful "NEW" Gated Suite near MAYO CLINIC! Elevator included. Brand new construction! Designer furnished. Spacious Su ...
From $182 per night (USD)
Expedia
Click For Pricing
VRBO
Private in-law suite with full kitchen, washer/dryer, & central AC
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
By the Beach - In-Law Suite Our calendar is updated in real-time & our nightly rates are accurately displayed. Simply e ...
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VRBO
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Expedia
Quiet home on a cul-de-sac with screened patio, W/D, & central AC
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
By the Beach - Main Our calendar is updated in real-time & our nightly rates are accurately displayed. Simply enter you ...
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Expedia
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VRBO
Renovated home + in-law suite near the beach with patio, 2 kitchens, AC, & W/Ds
Bedrooms:
3
Bathrooms:
5
Sleeps:
10
By the Beach - Full Property Our calendar is updated in real-time & our nightly rates are accurately displayed. Simply ...
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VRBO
From $142 per night (USD)
Expedia
The Cozy House by Mayo
Bedrooms:
2
Bathrooms:
2
Sleeps:
4
--- **Modern Coastal Retreat Near Mayo Clinic & Beaches – Ideal for Long-Term Stays** Enjoy comfort, convenience, and ...
From $142 per night (USD)
Expedia
From $202 per night (USD)
VRBO
Fun 5 Star Hot Tub/Beaches getaway Near MAYO!
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Private quiet 3 Bedroom Home 1300 Sq. Ft. Dedicated workspace and fast WIFI. 3 TVs with Netflix, Hulu, ROKU. Just 5 min ...
From $202 per night (USD)
VRBO
From $344 per night (USD)
Expedia
Tres Palmas!Renovated Pool Home Near Mayo & Beach!
Bedrooms:
2
Bathrooms:
4
Sleeps:
6
Comfort, location, and calm! From the moment you arrive at Las Palmas you will feel that the home has been designed with ...
From $344 per night (USD)
Expedia
From $210 per night (USD)
VRBO
Minutes away from Mayo Clinic, jax Beach, UNF, Ponte Vedra Beach, and PGA & TPC.
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Fully-Furnished 3 bedroom 2 bathroom, quite neighborhood, higher ceiling in the living area. Little storage in the back ...
From $210 per night (USD)
VRBO
From $281 per night (USD)
Expedia
Be A Nomad | Spacious 4 BR Close to Mayo & Beaches
Bedrooms:
2
Bathrooms:
4
Sleeps:
8
Relax and unwind in a beachy-style bungalow with a short 8-minute drive to the ocean! Nearby to Mayo Clinic and local re ...
From $281 per night (USD)
Expedia
From $151 per night (USD)
VRBO
Be A Nomad | Spacious 1 King BR close Beach & Mayo
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
Take it easy at this unique and tranquil getaway. Private space with brand new furniture. Comfortable and cozy with a p ...
From $151 per night (USD)
VRBO
From $476 per night (USD)
Expedia
Be A Nomad | Spacious Home close to Mayo & Beaches
Bedrooms:
3
Bathrooms:
5
Sleeps:
10
Beachy Bungalow: 8 min to Ocean! Mayo Clinic is nearby. Cozy bedrooms, private deck, and brand-new furniture. Your coast ...
From $476 per night (USD)
Expedia
From $233 per night (USD)
VRBO
Charming 3-bedroom house in Jacksonville
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Your home away from home in Jacksonville with 3 bedrooms, including 2 king beds and 1 twin bed. This amazing house offer ...
From $233 per night (USD)
VRBO
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Expedia
Spacious 4-bedroom house in enchanting Jacksonville with WiFi, AC
Bedrooms:
3
Bathrooms:
4
Sleeps:
8
Your home away from home in Jacksonville with 4 lovely bedrooms. Each room is thoughtfully furnished with 1 king bed, 2 ...
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Expedia
From $403 per night (USD)
VRBO
Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
Make yourself at home in this charming 3-bedroom, 2 bathroom Jacksonville Beach retreat. With a king bed, full bed, and ...
From $403 per night (USD)
VRBO
From $405 per night (USD)
Expedia
5 min to Mayo—luxury, comfort & care designed for patients & caregivers.
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
Whether you're traveling as a patient or simply seeking a peaceful getaway, Rest and Wellness by Doctor offers comfort, ...
From $405 per night (USD)
Expedia
From $297 per night (USD)
VRBO
Saltwater Pool I Firepits I Large Fenced Backyard I 4 Miles to Beach
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Welcome to the Turquoise Oasis! This charming 3-bedroom, 2.5-bath home features a first-floor primary suite, a sparkling ...
From $297 per night (USD)
VRBO
From $444 per night (USD)
Expedia
SMV Palm Escape Retreat nr Mayo
Bedrooms:
2
Bathrooms:
4
Sleeps:
10
Unwind by the sparkling private pool, practice your swing on the putting green, or sip a drink at the outdoor bar and gr ...
From $444 per night (USD)
Expedia
From $299 per night (USD)
VRBO
Modern 4BR Jax | Pool Oasis Near Beach | Backyard
Bedrooms:
2
Bathrooms:
4
Sleeps:
8
Escape to this private Jacksonville oasis! A 4-bedroom, 2-bath retreat with a sparkling pool, outdoor grill, cozy fire p ...
From $299 per night (USD)
VRBO
From $343 per night (USD)
Expedia
4BR w/ Pool Near Jax Beach | Good Morning Rentals
Bedrooms:
2
Bathrooms:
4
Sleeps:
8
Welcome to your private 4BR pool retreat just 5 minutes from Jax Beach! This single-family home in Jacksonville offers 4 ...
From $343 per night (USD)
Expedia
From $245 per night (USD)
VRBO
Pet-Friendly Rental, Pool Table, 7 Min to Mayo Clinic!
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Welcome to Your Jacksonville Beachside Retreat! Discover the perfect blend of comfort, convenience, and vibrant fun in o ...
From $245 per night (USD)
VRBO
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Expedia
Dog-friendly waterfront home with private dock, boat lift, pool and spa
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
Reel Relaxed Our calendar is updated in real-time & our nightly rates are accurately displayed. Simply enter your desir ...
Click For Pricing
Expedia
From $203 per night (USD)
VRBO
Beautiful Beach Studio~only 5 Minutes from the Beach
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
<p>Your Jacksonville Beach getaway starts here — a pet-friendly studio with an efficiency kitchen, smart TV, and lockbox ...
From $203 per night (USD)
VRBO
From $291 per night (USD)
VRBO
Beautifully restored Mediterranean home designed for comfort, healing, and rest.
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Beautifully restored Mediterranean-style home, thoughtfully designed for comfort, healing, and rest. Whether you're visi ...
From $291 per night (USD)
VRBO
From $280 per night (USD)
VRBO
Canal-Front Retreat 4 Mi to Jacksonville Beach!
Bedrooms:
3
Bathrooms:
4
Sleeps:
8
2 Mi to Mayo Clinic | BBQ-Ready Patio | Private Yard w/ Water Views Sunshine and serenity await at this Jacksonville va ...
From $280 per night (USD)
VRBO
From $125 per night (USD)
Expedia
Cozy Apt min to Mayo*Beaches*Free Wi-Fi*Coffee*Tea
Bedrooms:
1
Bathrooms:
1
Sleeps:
3
Make yourself at home in this marvelous 1-bedroom Jacksonville retreat within minutes of Mayo Clinic and the Beaches. Wi ...
From $125 per night (USD)
Expedia
From $421 per night (USD)
VRBO
Northeast Florida Retreat
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
Elegant Waterfront Haven | Dock, Boat Lift, Pool | Dog-Friendly Welcome to Coastal Serenity—a stylish single-level retr ...
From $421 per night (USD)
VRBO
From $182 per night (USD)
Expedia
Quiet Coastal Home w/ Patio Near Beaches
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Quiet Coastal Home w/ Patio Near Beaches Sunny Cul-de-Sac Retreat Near Jacksonville Beaches Nestled on a quiet cul-de- ...
From $182 per night (USD)
Expedia
From $156 per night (USD)
VRBO
Modern In-Law Suite Near Jax Beaches & Mayo
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Modern In-Law Suite Near Jax Beaches & Mayo Modern In-Law Suite Near Beaches & Mayo Clinic Relax in comfort at this pr ...
From $156 per night (USD)
VRBO

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Isle of Palms Rentals

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Results: 47 Rentals