Isle of Palms South, Florida Vacation Rentals. Book Beach Rentals, Lake Houses, Condos, Cabins, Villas, and Homes in Isle of Palms South, Florida on RentalSaver.com!

Isle of Palms South Rentals

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VRBO
Spacious 4-bedroom house in enchanting Jacksonville with WiFi, AC
Bedrooms:
3
Bathrooms:
4
Sleeps:
8
Your home away from home in Jacksonville with 4 lovely bedrooms. Each room is thoughtfully furnished with 1 king bed, 2 ...
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VRBO
From $426 per night (USD)
Expedia
5 min to Mayo—luxury, comfort & care designed for patients & caregivers.
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
Whether you're traveling as a patient or simply seeking a peaceful getaway, Rest and Wellness by Doctor offers comfort, ...
From $426 per night (USD)
Expedia
From $301 per night (USD)
VRBO
Modern 4BR Jax | Pool Oasis Near Beach | Backyard
Bedrooms:
2
Bathrooms:
4
Sleeps:
8
Escape to this private Jacksonville oasis! A 4-bedroom, 2-bath retreat with a sparkling pool, outdoor grill, cozy fire p ...
From $301 per night (USD)
VRBO
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Expedia
Waterfront Jacksonville Retreat w/ Boat Dock!
Bedrooms:
3
Bathrooms:
4
Sleeps:
8
Located in the vibrant city of Jacksonville, this 4-bedroom, 3-bath vacation rental is the ideal base for exploring all ...
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Expedia
From $348 per night (USD)
VRBO
Lux Pool Home Close to Mayo & Jacksonville Beach!
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
This freshly remodeled open concept, pool home, close to Mayo Clinic and Jax beach is sure to wow you! The home includes ...
From $348 per night (USD)
VRBO
From $284 per night (USD)
Expedia
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
Bedrooms:
3
Bathrooms:
4
Sleeps:
10
*New to VRBO* Welcome to “The Cottage” a recently remodeled spacious and accessible brick ranch home in the heart of Ja ...
From $284 per night (USD)
Expedia
From $224 per night (USD)
VRBO
Pablo Pointe- Single Family Home directly across from the Mayo Clinic
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
We invite you to stay at Pablo Pointe, our new fully renovated family ranch home. Ideal for families and/or patients vis ...
From $224 per night (USD)
VRBO
From $182 per night (USD)
Expedia
Amazing New MAYO King Suite
Bedrooms:
1
Bathrooms:
1
Sleeps:
3
Beautiful "NEW" Gated Suite near MAYO CLINIC! Elevator included. Brand new construction! Designer furnished. Spacious Su ...
From $182 per night (USD)
Expedia
From $210 per night (USD)
VRBO
Minutes away from Mayo Clinic, jax Beach, UNF, Ponte Vedra Beach, and PGA & TPC.
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Fully-Furnished 3 bedroom 2 bathroom, quite neighborhood, higher ceiling in the living area. Little storage in the back ...
From $210 per night (USD)
VRBO
From $289 per night (USD)
Expedia
Be A Nomad | Spacious 4 BR Close to Mayo & Beaches
Bedrooms:
2
Bathrooms:
4
Sleeps:
8
Relax and unwind in a beachy-style bungalow with a short 8-minute drive to the ocean! Nearby to Mayo Clinic and local re ...
From $289 per night (USD)
Expedia
From $163 per night (USD)
VRBO
Be A Nomad | Spacious 1 King BR close Beach & Mayo
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
Take it easy at this unique and tranquil getaway. Private space with brand new furniture. Comfortable and cozy with a p ...
From $163 per night (USD)
VRBO
From $523 per night (USD)
Expedia
Be A Nomad | Spacious Home close to Mayo & Beaches
Bedrooms:
3
Bathrooms:
5
Sleeps:
10
Beachy Bungalow: 8 min to Ocean! Mayo Clinic is nearby. Cozy bedrooms, private deck, and brand-new furniture. Your coast ...
From $523 per night (USD)
Expedia
From $237 per night (USD)
VRBO
Charming 3-bedroom house in Jacksonville
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Your home away from home in Jacksonville with 3 bedrooms, including 2 king beds and 1 twin bed. This amazing house offer ...
From $237 per night (USD)
VRBO
From $229 per night (USD)
Expedia
The Retreat close to Mayo Clinic!
Bedrooms:
1
Bathrooms:
3
Sleeps:
6
Book with confidence with an experienced host! The Retreat is a fully renovated 3 bedroom/2 bathroom house. Guests are ...
From $229 per night (USD)
Expedia
From $372 per night (USD)
VRBO
Fancy private pool home in Jax beach
Bedrooms:
2
Bathrooms:
4
Sleeps:
10
Have fun with the whole family at this stylish place. This house offers a relaxing feel for family and friends vacation ...
From $372 per night (USD)
VRBO
From $326 per night (USD)
Expedia
Mayo Clinic townhouse in San Pablo with Primary suite located on the 1st floor
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Beautiful townhouse located in the sought after San Pablo area. Fully furnished 3 bedroom, 2.5 bathrooms and 2 car garag ...
From $326 per night (USD)
Expedia
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VRBO
Tranquil Retreat 4BD/4BTH-Marshviews & Pool SLP 10
Bedrooms:
2
Bathrooms:
4
Sleeps:
10
Welcome to Marsh View: Managed exclusively by Welcome Home Rentals Jax Beach. This property is a 4 bedroom 2 bathroom, p ...
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VRBO
From $351 per night (USD)
Expedia
Comfy Mayo Retreat; Heated Pool, Close to Beach
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
Just listed!! 3 bedroom 2 bath pool home. Only 1 mile from Mayo and 3 miles from Jacksonville Beach. The home is all one ...
From $351 per night (USD)
Expedia
From $350 per night (USD)
VRBO
Modern Townhouse minutes from Mayo Clinic UNF & Beach
Bedrooms:
2
Bathrooms:
3
Sleeps:
9
Beautiful townhouse located in the sought after San Pablo area. Fully furnished 3 Bedroom, 2.5 bathroom & car garage. Th ...
From $350 per night (USD)
VRBO
From $2270 per night (USD)
Expedia
HCB 53 Suenos Luxury Yacht
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
Want to ride to the sandbar in Style? Fort George, Bird Island, Matanzas Inlet in St. Augustine? This is a NÉW 53 foot ...
From $2270 per night (USD)
Expedia
From $241 per night (USD)
VRBO
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
Bedrooms:
3
Bathrooms:
4
Sleeps:
8
We believe that you will feel right at home in our bungalow. The backyard will feel like an oasis with a comfortable con ...
From $241 per night (USD)
VRBO
From $295 per night (USD)
Expedia
Turquoise Oasis I Family & Dog Friendly I Saltwater Pool I Firepits
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Welcome to the Turquoise Oasis! This charming 3-bedroom, 2.5-bath home features a first-floor primary suite, a sparkling ...
From $295 per night (USD)
Expedia
From $445 per night (USD)
VRBO
SMV Palm Escape Retreat nr Mayo
Bedrooms:
2
Bathrooms:
4
Sleeps:
10
Unwind by the sparkling private pool, practice your swing on the putting green, or sip a drink at the outdoor bar and gr ...
From $445 per night (USD)
VRBO
From $477 per night (USD)
Expedia
New 2 miles 2Mayo Clinic Intracoastal water views Mins to JaxBeach
Bedrooms:
3
Bathrooms:
4
Sleeps:
8
🛏️ 4 Bedrooms | 3 Bath 🍷 Free wine! 📶 Free Wi-Fi 🚘 Free parking 🛶 Private dock 🔥 Outdoor seating 📺 TV in every r ...
From $477 per night (USD)
Expedia
From $261 per night (USD)
VRBO
5min To Mayo Clinic & Beach Luxury Suite with 2 King Beds
Bedrooms:
2
Bathrooms:
2
Sleeps:
6
ELITE MAYO CLINIC LUXURY RETREAT | 5 MIN TO BEACH Experience Jacksonville's finest! Steps from Mayo Clinic in prestigio ...
From $261 per night (USD)
VRBO
From $397 per night (USD)
Expedia
Mayo Clinc 1mile from Intercoastal waterfront home w/pool and Breathtaking Views
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
Enjoy amazing water views from EVERY single room in this newly renovated ICW pool home (renovated in March 2016 / Pool N ...
From $397 per night (USD)
Expedia
From $104 per night (USD)
VRBO
The Petite Retreat - Walk to Mayo Clinic!
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
The Petite Retreat is fully renovated. This cozy studio/In-law suite features: +king bed +ensuite bathroom +full siz ...
From $104 per night (USD)
VRBO
From $210 per night (USD)
Expedia
North East Florida Retreat
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Fabulous beach blvd townhome- with backyard sun room, fire pit, pool table, dart board- something for the whole family! ...
From $210 per night (USD)
Expedia
From $246 per night (USD)
VRBO
Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
Make yourself at home in this charming 3-bedroom, 2 bathroom Jacksonville Beach retreat. With a king bed, full bed, and ...
From $246 per night (USD)
VRBO
From $272 per night (USD)
VRBO
Beautiful Coastal Home near Mayo Clinic. Pet Friendly!
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Come and relax at this impeccably clean and cozy coastal home less than 3 minutes from the Mayo Clinic Jacksonville, 7 m ...
From $272 per night (USD)
VRBO
From $142 per night (USD)
VRBO
The Cozy House by Mayo
Bedrooms:
2
Bathrooms:
2
Sleeps:
4
--- **Modern Coastal Retreat Near Mayo Clinic & Beaches – Ideal for Long-Term Stays** Enjoy comfort, convenience, and ...
From $142 per night (USD)
VRBO
From $202 per night (USD)
Expedia
Fun 5 Star Hot Tub/Beaches getaway Near MAYO!
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Private quiet 3 Bedroom Home 1300 Sq. Ft. Dedicated workspace and fast WIFI. 3 TVs with Netflix, Hulu, ROKU. Just 5 min ...
From $202 per night (USD)
Expedia
From $730 per night (USD)
VRBO
Ideal for Mayo Clinic Visitors: 3 Spacious Suites w/ Kitchen and Pool Access
Bedrooms:
3
Bathrooms:
3
Sleeps:
12
With easy access to Highway 202, we're conveniently located near Mayo Clinic, east of Jacksonville. Explore the city: 3 ...
From $730 per night (USD)
VRBO
From $243 per night (USD)
VRBO
Cozy Suite w/ Kitchen, Heated Pool, & Free Shuttle to Mayo Clinic – Free Parking
Bedrooms:
1
Bathrooms:
1
Sleeps:
4
With easy access to Highway 202, we're conveniently located near Mayo Clinic, east of Jacksonville. Explore the city: 3 ...
From $243 per night (USD)
VRBO
From $487 per night (USD)
VRBO
2 Spacious Suites w/ Kitchen, Free Breakfast, and Heated Pool Near Mayo Clinic
Bedrooms:
2
Bathrooms:
2
Sleeps:
8
With easy access to Highway 202, we're conveniently located near Mayo Clinic, east of Jacksonville. Explore the city: 3 ...
From $487 per night (USD)
VRBO
From $230 per night (USD)
VRBO
Spacious Room w/ Full Kitchen, Free Hot Breakfast & Free Shuttle to Mayo Clinic
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
With easy access to Highway 202, we're conveniently located near Mayo Clinic, east of Jacksonville. Explore the city: 3 ...
From $230 per night (USD)
VRBO
From $974 per night (USD)
VRBO
4 Comfort-Focused Suites w/ Kitchen, Heated Pool Access & Mayo Clinic Shuttle
Bedrooms:
4
Bathrooms:
4
Sleeps:
16
With easy access to Highway 202, we're conveniently located near Mayo Clinic, east of Jacksonville. Explore the city: 3 ...
From $974 per night (USD)
VRBO
From $236 per night (USD)
Expedia
Pet-Friendly Rental, Pool Table, 7 Min to Mayo Clinic!
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
Welcome to Your Jacksonville Beachside Retreat! Discover the perfect blend of comfort, convenience, and vibrant fun in o ...
From $236 per night (USD)
Expedia
From $406 per night (USD)
VRBO
Pool home on the Water near Mayo
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Coastal Canal Retreat | Pool • 3BR Welcome to your serene escape on the water! This home is nestled on a quiet canal jus ...
From $406 per night (USD)
VRBO
From $294 per night (USD)
VRBO
Beautifully restored Mediterranean home designed for comfort, healing, and rest.
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Beautifully restored Mediterranean-style home, thoughtfully designed for comfort, healing, and rest. Whether you're visi ...
From $294 per night (USD)
VRBO
From $207 per night (USD)
VRBO
The Lily House- Flexible Lease Terms, Hospitals and Beaches
Bedrooms:
3
Bathrooms:
3
Sleeps:
8
Come enjoy the sunshine state and plenty of natural light throughout this brand new, fully furnished townhome- minutes t ...
From $207 per night (USD)
VRBO
From $170 per night (USD)
Expedia
Brockway · Cozy JAX Beach Home: Close to Beach/Mayo/UNF
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Summary: Entire cozy, relaxing, and peaceful home. Queen bed in the master bedroom and expandable queen daybed in the gu ...
From $170 per night (USD)
Expedia
From $363 per night (USD)
VRBO
Mayo Clinic 1.8 miles #2 Your Home Away From Home
Bedrooms:
2
Bathrooms:
3
Sleeps:
5
This 3 /2 is located in the quiet neighborhood of Isle of Palms. It has been fully remodeled inside and out. Extra cle ...
From $363 per night (USD)
VRBO
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Expedia
5 bedroom home with heated pool and hot tub
Bedrooms:
4
Bathrooms:
5
Sleeps:
10
Beautiful 5 bedroom home with four baths. Heated pool and hot tub with jets enclosed with a cage. Outdoor fireplace and ...
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Expedia
From $264 per night (USD)
VRBO
New Townhome Lake View, Minutes to Mayo & Beaches
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
Just Listed! New Built Townhouse with Lake View in a gated community. 3 bedroom, 2.5 bathrooms with 2 car garage. Master ...
From $264 per night (USD)
VRBO
From $419 per night (USD)
Expedia
Peaceful Getaway Heated Pool Mayo Jags Games Beach
Bedrooms:
2
Bathrooms:
4
Sleeps:
8
Experience tranquility at Osprey’s Rest, a pet-friendly beach house in Jacksonville Beach’s serene Isle of Palms neighbo ...
From $419 per night (USD)
Expedia
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VRBO
Waterfront Oasis - 5 bedrooms, private pool and 2 docks
Bedrooms:
4
Bathrooms:
5
Sleeps:
10
Discover the epitome of luxury living at the "Chateau Coquina"—a haven that seamlessly combines opulence with the allure ...
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VRBO
From $568 per night (USD)
Expedia
Tres Palmas!Renovated Pool Home Near Mayo & Beach!
Bedrooms:
2
Bathrooms:
4
Sleeps:
6
Comfort, location, and calm! From the moment you arrive at Las Palmas you will feel that the home has been designed with ...
From $568 per night (USD)
Expedia
From $167 per night (USD)
VRBO
Private in-law suite with full kitchen, washer/dryer, & central AC
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
By the Beach - In-Law Suite Our calendar is updated in real-time & our nightly rates are accurately displayed. Simply e ...
From $167 per night (USD)
VRBO
From $213 per night (USD)
Expedia
Quiet home on a cul-de-sac with screened patio, W/D, & central AC
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
By the Beach - Main Our calendar is updated in real-time & our nightly rates are accurately displayed. Simply enter you ...
From $213 per night (USD)
Expedia
From $338 per night (USD)
VRBO
Renovated home + in-law suite near the beach with patio, 2 kitchens, AC, & W/Ds
Bedrooms:
3
Bathrooms:
5
Sleeps:
10
By the Beach - Full Property Our calendar is updated in real-time & our nightly rates are accurately displayed. Simply ...
From $338 per night (USD)
VRBO
From $368 per night (USD)
Expedia
Your Home Away From Home and 2 miles from The Mayo Clinic and Snowbirds welcomed
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
3 bedroom 2 bath home newly renovated located in a quiet neighborhood 2 miles from Mayo Clinic and a few minutes from th ...
From $368 per night (USD)
Expedia
From $369 per night (USD)
VRBO
Manatee House: Private Marsh View Retreat - 1 Mile to Mayo, 5 Miles to Beaches
Bedrooms:
3
Bathrooms:
4
Sleeps:
12
You will love this beautiful and comfortable large marsh view home. Perfect location in a quiet neighborhood within walk ...
From $369 per night (USD)
VRBO
From $244 per night (USD)
VRBO
NEW- The Cove at San Pablo- Across from the Mayo Clinic
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
**NEW** Welcome to the Cove at San Pablo! Come visit Jax and relax in our newly renovated and fully furnished with 3 bed ...
From $244 per night (USD)
VRBO
From $814 per night (USD)
VRBO
Dog-friendly waterfront home with private dock, boat lift, pool and spa
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
Reel Relaxed Our calendar is updated in real-time & our nightly rates are accurately displayed. Simply enter your desir ...
From $814 per night (USD)
VRBO

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Isle of Palms South Rentals

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Results: 55 Rentals