
Seneca Rentals
- From $508 per night (USD)
VRBO
Tee House on BEAUTIFUL Lake Keowee
- Bedrooms:
- 4
- Bathrooms:
- 4
- Sleeps:
- 8
Waterfront on beautiful Lake Keowee.. Only minutes to Clemson Death Valley for all the college sports.. Take a short wal ...
From $508 per night (USD)VRBO
- From $143 per night (USD)
Expedia
Historic Seneca Bungalow
- Bedrooms:
- 1
- Bathrooms:
- 2
- Sleeps:
- 4
This location is perfect to relax with boutique shopping and eating on Ram Cat Alley in downtown Seneca only 2 blocks aw ...
From $143 per night (USD)Expedia
- From $470 per night (USD)
VRBO
Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock
- Bedrooms:
- 2
- Bathrooms:
- 4
- Sleeps:
- 8
This cozy 4 Br cottage has all the amenities of home and feels just as comfortable. With over 16 feet of sliding doors ...
From $470 per night (USD)VRBO
- From $664 per night (USD)
Expedia
Comfortably Designed Lake Keowee Waterfront, Minutes to Clemson- In Seneca
- Bedrooms:
- 4
- Bathrooms:
- 5
- Sleeps:
- 10
Enjoy this like newly renovated retreat on Lake Keowee. Comfortably designed and professionally decorated by Trio Inter ...
From $664 per night (USD)Expedia
- From $354 per night (USD)
VRBO
Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!
- Bedrooms:
- 3
- Bathrooms:
- 3
- Sleeps:
- 8
Escape to a lakeside retreat just 5 minutes from downtown Seneca. Our 3-bedroom, 3-bathroom home offers the perfect plac ...
From $354 per night (USD)VRBO
- From $662 per night (USD)
VRBO
Lake Keowee: Lake front 7 mi from Clemson stadium
- Bedrooms:
- 3
- Bathrooms:
- 3
- Sleeps:
- 10
Comfortable, newly remodeled open plan house on Lake Keowee- south end -10 minute drive from Clemson's Death Valley or a ...
From $662 per night (USD)VRBO
- From $151 per night (USD)
VRBO
Beautiful home near Clemson
- Bedrooms:
- 1
- Bathrooms:
- 2
- Sleeps:
- 4
Convenient to anywhere you would like to be in our area. Less than a mile from shops, restaurants, breweries, Jazz on th ...
From $151 per night (USD)VRBO
- From $1440 per night (USD)
Expedia
Family Retreat on South Cove of Lake Keowee; Private Dock; ~ 10 Mi from Clemson
- Bedrooms:
- 3
- Bathrooms:
- 5
- Sleeps:
- 14
Welcome to this newly renovated lakefront retreat, nestled on the south end of picturesque Lake Keowee. This stunning ho ...
From $1440 per night (USD)Expedia
- From $508 per night (USD)
VRBO
South Cove Cottage 5 bedroom
- Bedrooms:
- 2
- Bathrooms:
- 5
- Sleeps:
- 10
Welcome to our stunning 5-bedroom home with a cove view of beautiful Lake Keowee! Nestled in a quiet cove, this spacious ...
From $508 per night (USD)VRBO
- From $215 per night (USD)
Expedia
Boutique hotel in historic downtown Seneca. Room #2 Owners Suite. Q/K combo.
- Bedrooms:
- 1
- Bathrooms:
- 1
- Sleeps:
- 4
Welcome to the heart of downtown Seneca, South Carolina. Formerly the Richardson Theatre in the late 50s, our building ...
From $215 per night (USD)Expedia
- From $220 per night (USD)
VRBO
Boutique hotel in historic downtown Seneca. Room #4, King bed.
- Bedrooms:
- 1
- Bathrooms:
- 1
- Sleeps:
- 2
Welcome to the heart of downtown Seneca, South Carolina. Formerly the Richardson Theatre in the late 50s, our building ...
From $220 per night (USD)VRBO
- From $204 per night (USD)
Expedia
Private Room #3
- Bedrooms:
- 1
- Bathrooms:
- 1
- Sleeps:
- 4
Welcome to the heart of downtown Seneca, South Carolina. Formerly the Richardson Theatre in the late 50s, our building ...
From $204 per night (USD)Expedia
- From $220 per night (USD)
VRBO
Boutique hotel in historic downtown Seneca. Room #6, King Bed.
- Bedrooms:
- 1
- Bathrooms:
- 1
- Sleeps:
- 2
Welcome to the heart of downtown Seneca, South Carolina. Formerly the Richardson Theatre in the late 50s, our building ...
From $220 per night (USD)VRBO
- From $204 per night (USD)
Expedia
Boutique hotel in historic downtown Seneca. Room #5, two King beds.
- Bedrooms:
- 1
- Bathrooms:
- 1
- Sleeps:
- 4
Welcome to the heart of downtown Seneca, South Carolina. Formerly the Richardson Theatre in the late 50s, our building ...
From $204 per night (USD)Expedia
- From $204 per night (USD)
VRBO
Boutique hotel in historic downtown Seneca. Room#1, Q/K combo.
- Bedrooms:
- 1
- Bathrooms:
- 1
- Sleeps:
- 4
Welcome to the heart of downtown Seneca, South Carolina. Formerly the Richardson Theatre in the late 50s, our building ...
From $204 per night (USD)VRBO
- From $760 per night (USD)
VRBO
Knot On Call Lake House + HOT TUB
- Bedrooms:
- 3
- Bathrooms:
- 4
- Sleeps:
- 12
Welcome to our 4-bedroom, 3 bathroom lakefront retreat on the serene shores of Lake Keowee! Located 10 minutes to Clems ...
From $760 per night (USD)VRBO
- From $402 per night (USD)
VRBO
Lake Keowee Waterfront Town Home - 3 Bdrm, 3.5 Bath 7 Miles from Clemson Stadium
- Bedrooms:
- 3
- Bathrooms:
- 3
- Sleeps:
- 10
Make memories of a lifetime in this cozy, waterfront Town home on Lake Keowee. Beautiful sunset views, community pool 1 ...
From $402 per night (USD)VRBO
- From $381 per night (USD)
Expedia
Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
- Bedrooms:
- 1
- Bathrooms:
- 3
- Sleeps:
- 8
Step back in time in this renovated 1940 historic bungalow in downtown Seneca, SC. This charming 3BR, 1.5BA home sleeps ...
From $381 per night (USD)Expedia
- From $328 per night (USD)
VRBO
New! The Tiger's Perch- Close to Clemson.
- Bedrooms:
- 2
- Bathrooms:
- 4
- Sleeps:
- 8
🛏 4 Comfortable Bedrooms – Thoughtfully decorated with cozy bedding and ample storage. 🛁 2 Full Bathrooms – Clean, upd ...
From $328 per night (USD)VRBO
- From $628 per night (USD)
Expedia
The Big Golf House- 10 miles to Clemson
- Bedrooms:
- 4
- Bathrooms:
- 4
- Sleeps:
- 10
Welcome to your spacious golf course retreat in Seneca, South Carolina, just 15 minutes from Clemson University and minu ...
From $628 per night (USD)Expedia
- From $311 per night (USD)
VRBO
8 Mi to Clemson: Peaceful Family Home w/ Yard
- Bedrooms:
- 1
- Bathrooms:
- 3
- Sleeps:
- 6
BBQ Ready | 4 Mi to Lake Keowee | On-Site Creek | Close to Publix Escape the hustle of everyday life and savor the fres ...
From $311 per night (USD)VRBO
- From $529 per night (USD)
Expedia
Lakefront Fun Near Clemson! Retreat w/ Pool Access
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 6
Lake-View Deck w/ Smart TV | Family-Friendly Layout | Paddleboards Game day or lake day — the choice is yours at this ...
From $529 per night (USD)Expedia
- From $687 per night (USD)
VRBO
The Nest Above - Sparrow Suite
- Bedrooms:
- 1
- Bathrooms:
- 1
- Sleeps:
- 2
Stylish one-bedroom, one-bath downtown loft featuring exposed brick, rich hardwood floors, and abundant natural light. T ...
From $687 per night (USD)VRBO
- From $687 per night (USD)
Expedia
The Nest Above - Finch Suite
- Bedrooms:
- 1
- Bathrooms:
- 1
- Sleeps:
- 2
Charming downtown loft featuring exposed brick walls, warm hardwood floors, and large windows that fill the space with n ...
From $687 per night (USD)Expedia
- From $608 per night (USD)
VRBO
The Nest Above- Hummingbird
- Bedrooms:
- 2
- Bathrooms:
- 2
- Sleeps:
- 4
Welcome to the hummingbird suite at The Nest Above. A beautifully restored loft in the heart of downtown Seneca, just st ...
From $608 per night (USD)VRBO
- From $335 per night (USD)
Expedia
Carolina Cottage Retreat-12 Minutes from Clemson University
- Bedrooms:
- 2
- Bathrooms:
- 4
- Sleeps:
- 8
Your cozy getaway awaits in Seneca at this superb cottage. This spacious 4BR/2BA is just 12 minutes from Clemson Univers ...
From $335 per night (USD)Expedia
- From $336 per night (USD)
VRBO
Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 6
Enjoy a relaxing family friendly stay near Clemson, Seneca, and Lake Keowee. This spacious 3BR/2BA entire home is perfec ...
From $336 per night (USD)VRBO
- From $275 per night (USD)
Expedia
Close to Clemson and Lake Keowee and Downtown Seneca
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 7
Whether a short 15 minute drive to Clemson, a 5 minute drive to lake Keowee, or a mile drive to charming downtown Seneca ...
From $275 per night (USD)Expedia
- From $734 per night (USD)
VRBO
Porch & Paddle- A New Lakeside Addition
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 7
Welcome to Porch & Paddle, a beautifully designed, brand-new lakefront retreat on Lake Keowee, located in the heart of S ...
From $734 per night (USD)VRBO
- From $850 per night (USD)
Expedia
Close to Clemson with a beautiful view of Keowee!
- Bedrooms:
- 4
- Bathrooms:
- 4
- Sleeps:
- 11
Serene Lake Hartwell Retreat – Relax on the screened porch of this charming 1935 farmhouse nestled among towering oaks. ...
From $850 per night (USD)Expedia
- From $375 per night (USD)
VRBO
Near Lake Keowee - Pool - Gameroom
- Bedrooms:
- 2
- Bathrooms:
- 3
- Sleeps:
- 12
Relax at this modern 3BR, 2BA home in Seneca, SC near Lake Keowee and Clemson University. Enjoy a private pool perfect f ...
From $375 per night (USD)VRBO
- From $944 per night (USD)
VRBO
The Keowee Canopy Retreat Life: Custom Lakefront Gem With Unbeatable Views!
- Bedrooms:
- 4
- Bathrooms:
- 5
- Sleeps:
- 12
Welcome to The Keowee Life! Your dream family getaway awaits at this stunning, custom-built 3-story lake house designed ...
From $944 per night (USD)VRBO
- From $382 per night (USD)
VRBO
Renovated 3BR near Lake Keowee & Clemson
- Bedrooms:
- 1
- Bathrooms:
- 3
- Sleeps:
- 6
Welcome to our fully renovated 3-bedroom, 1.5-bath home in Seneca, one mile from the Lake Keowee boat launch and 7 miles ...
From $382 per night (USD)VRBO

































