Saint Charles Area, Missouri Vacation Rentals. Book Beach Rentals, Lake Houses, Condos, Cabins, Villas, and Homes in Saint Charles Area, Missouri on RentalSaver.com!

Saint Charles Area Rentals

Filter

Popular Areas

From $850 per night (USD)
VRBO
Victorian Gem Steps from Main St - Sleeps 9 & Pets
Bedrooms:
3
Bathrooms:
4
Sleeps:
9
Summary: Escape to a lovingly restored 4‑bed Victorian home just steps from Historic Main Street and the Missouri River ...
From $850 per night (USD)
VRBO
From $224 per night (USD)
Expedia
Honky Tonk Hideaway
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Welcome to the Honky Tonk Hideaway nestled near the historic charm of Main Street in Saint Charles! This inviting house ...
From $224 per night (USD)
Expedia
From $151 per night (USD)
VRBO
New Melle Apartment Near Missouri Wine Country
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
Explore the best of St. Charles County with ease from this charming vacation rental in New Melle wine country. The 1-bed ...
From $151 per night (USD)
VRBO
From $245 per night (USD)
Expedia
Rhythm Loft Above the Honky Tonk
Bedrooms:
1
Bathrooms:
2
Sleeps:
6
2 bedroom/1 bathroom western themed unit located just a short walk from the historic Main Street district. are ONLY dog ...
From $245 per night (USD)
Expedia
From $251 per night (USD)
VRBO
Backstage Loft Above Honky Tonk
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Welcome to the Wild West Getaway, our charming, 2 bedroom/1 bathroom apartment located in the heart of historic St. Char ...
From $251 per night (USD)
VRBO
From $269 per night (USD)
Expedia
The Loft on Main | Steps to Dining & Nightlife
Bedrooms:
1
Bathrooms:
1
Sleeps:
5
Stay right in the heart of Historic Main Street! This spacious owner’s suite is steps from popular shops, restaurants, b ...
From $269 per night (USD)
Expedia
From $181 per night (USD)
VRBO
Cozy Front Lake Home in Newtown St. Charles
Bedrooms:
2
Bathrooms:
4
Sleeps:
8
Nestled in the heart of New Town St. Charles, our cozy home offers a perfect blend of comfort, style, and convenience fo ...
From $181 per night (USD)
VRBO
From $205 per night (USD)
Expedia
‘The Merlot Bungalow’ Defiance Tiny Home on Trail
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
Escape the hustle and bustle of St. Louis with a stay at this chic countryside vacation rental in Defiance, MO. 'Merlot ...
From $205 per night (USD)
Expedia
From $199 per night (USD)
VRBO
'The Chardonnay Chalet' Defiance Studio Trail!
Bedrooms:
1
Bathrooms:
1
Sleeps:
3
Experience a unique getaway to the countryside with your family or significant other when you book this modern tiny home ...
From $199 per night (USD)
VRBO
From $149 per night (USD)
VRBO
Business-Traveler Friendly 2-bedroom condo in fantastic Lake Saint Louis
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Your Lake Saint Louis adventure begins at this 2-bedroom condo. This charming property features 1 queen bed and 1 twin b ...
From $149 per night (USD)
VRBO
From $122 per night (USD)
VRBO
Cozy Loft from 1860 in Frenchtown facing Katy trail St Charles MO
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
Welcome to your dream loft in historic Frenchtown! This renovated 1860 loft combines vintage charm with modern convenien ...
From $122 per night (USD)
VRBO
From $138 per night (USD)
Expedia
Stunning Loft from 1860 in Frechtown St Charles Mo
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
This unique place has a style all its own. 1860's Historic Building in St Charles. Fully renovated with fresh paint, bac ...
From $138 per night (USD)
Expedia
From $302 per night (USD)
VRBO
Hot Tub Gazebo, Game Room with Arcade, 2 King Beds, Fire Pit - Sleeps 8
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
A spacious, fully stocked home with a hot tub beneath a private covered gazebo, a fire pit, a lower level game room, and ...
From $302 per night (USD)
VRBO
From $382 per night (USD)
Expedia
Pet-Friendly 2BR Townhome | Workspace
Bedrooms:
2
Bathrooms:
2
Sleeps:
4
Settle into a bright, modern O'Fallon townhome designed for easy weekends, work trips, and longer stays. The open main l ...
From $382 per night (USD)
Expedia
From $289 per night (USD)
VRBO
The Secret Sojourn | 3BR Game Room Home | Fenced Yard | Dog-Friendly O'Fallon
Bedrooms:
1
Bathrooms:
3
Sleeps:
8
The Secret Sojourn — 3BR with Media Room & Garage in O'Fallon, MO The basement media room is the centerpiece — a fully e ...
From $289 per night (USD)
VRBO
From $513 per night (USD)
Expedia
Vino Villa Wine Country Gem: Patio & Grill
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Close to Wineries, Hiking & Fishing | Game Room | Fire Pit Raise your glass and let the good times flow at this 3-bed, ...
From $513 per night (USD)
Expedia
From $263 per night (USD)
VRBO
Historic Augusta Cabin | Wine Country & Fire Pit
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Historic cabin comfort in Augusta wine country The Large Cabin blends rustic character with practical comfort for up to ...
From $263 per night (USD)
VRBO
From $250 per night (USD)
Expedia
Historic Augusta Log Cabin | Wine Country
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
The Small Cabin | Cozy Retreat in the Heart of Augusta Wine Country Discover the charm of Augusta wine country at The Sm ...
From $250 per night (USD)
Expedia
From $356 per night (USD)
VRBO
Charming Blake Cottage | Augusta Wine Country
Bedrooms:
1
Bathrooms:
3
Sleeps:
8
Charming Blake Cottage | Augusta Wine Country Escape to a charming modern farmhouse in Missouri wine country. This pet-f ...
From $356 per night (USD)
VRBO
$4-bed house in Wentzville next to restaurants/event space/\Free food and drink\$
From $375 per night (USD)
Expedia
4-bed house in Wentzville next to restaurants/event space/\"Free food and drink\"
Bedrooms:
2
Bathrooms:
4
Sleeps:
10
FREE food and drinks with every booking—welcome to The Rose! This beautifully restored 100-year-old home sits in the hea ...
From $375 per night (USD)
Expedia
From $521 per night (USD)
VRBO
Charming 3-bedroom house with WiFi, AC in O'Fallon
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Make yourself at home in this 3-bedroom O'Fallon retreat. This charming house boasts 1 king bed and 2 queen beds, perfec ...
From $521 per night (USD)
VRBO
From $190 per night (USD)
Expedia
Black & Gold suite 202 -ADA Room
Bedrooms:
1
Bathrooms:
1
Sleeps:
4
Stay in the center of the action in this one-of-a-kind place. This suite is in the 1st Capitol Mansion Boutique Hotel. ...
From $190 per night (USD)
Expedia
From $190 per night (USD)
VRBO
1st Capitol Mansion - Suite 302
Bedrooms:
1
Bathrooms:
1
Sleeps:
4
Stay in the center of the action in this one-of-a-kind place. This suite is in the 1st Capitol Mansion Boutique Hotel. ...
From $190 per night (USD)
VRBO
From $255 per night (USD)
VRBO
The Great Room - fully cozy & private Townhome
Bedrooms:
1
Bathrooms:
1
Sleeps:
6
Welcome to this brilliant townhouse in Saint Charles. This terrific property features a cozy bedroom with two comfortabl ...
From $255 per night (USD)
VRBO
From $409 per night (USD)
VRBO
Luxurious, spa-like retreat steps from Main St.
Bedrooms:
2
Bathrooms:
1
Sleeps:
2
When French Canadian fur trader Louis Blanchette arrived in 1769 in what we now know as St. Charles, he saw the beautifu ...
From $409 per night (USD)
VRBO
From $338 per night (USD)
Expedia
Charming, Pet friendly, Long stay discounts, 6 miles to Convention Center
Bedrooms:
2
Bathrooms:
3
Sleeps:
5
Your cozy getaway awaits in this lovely home. With 3 bedrooms our place is equipped for both long or short stays to make ...
From $338 per night (USD)
Expedia
From $545 per night (USD)
VRBO
T's Luxury Pool, Hot Tub, Home Theater & Arcade House Prime - St. Louis Airport
Bedrooms:
2
Bathrooms:
4
Sleeps:
14
Welcome to your luxurious retreat! This spacious *4-bedroom, 2.5-bathroom home* is designed to provide you with unmatche ...
From $545 per night (USD)
VRBO
From $660 per night (USD)
Expedia
The Chalet | St Charles 2BR Private Retreat on 1.2 Acres | By Mercer Stays
Bedrooms:
1
Bathrooms:
2
Sleeps:
5
Welcome to The Chalet by Mercer Stays 🌳 NEED MORE ROOM? BOOK THE BLOCK BY MERCER STAYS. Price Improvement 8/31/2026 T ...
From $660 per night (USD)
Expedia
From $566 per night (USD)
VRBO
The Getaway House | St Charles 4BR Sleeps 11 Game Room | Hot Tub | Mercer Stays
Bedrooms:
2
Bathrooms:
4
Sleeps:
11
DUE TO DEMAND - MUST READ: Starting August 31st, we`re adding a second master ensuite - king bed, private full bath - an ...
From $566 per night (USD)
VRBO
From $424 per night (USD)
Expedia
3BR Historic St. Charles, MO-Walking distance to Main Street
Bedrooms:
3
Bathrooms:
3
Sleeps:
6
Welcome to your perfect getaway! This charming 3-bedroom, 3-bathroom house is the ideal spot to relax and recharge durin ...
From $424 per night (USD)
Expedia
From $396 per night (USD)
VRBO
Walking distance to Historic Main Street, St. Charles, MO
Bedrooms:
3
Bathrooms:
3
Sleeps:
6
Welcome to your home away from home! This cozy 3-bedroom, 3-bathroom house is the perfect retreat for your stay in St. C ...
From $396 per night (USD)
VRBO
From $330 per night (USD)
VRBO
Saint Charles White House
Bedrooms:
3
Bathrooms:
5
Sleeps:
18
This 5-bedroom house is perfect for your escape to Saint Charles. Marvelous AC, WiFi, iron, heating, and a hair dryer ar ...
From $330 per night (USD)
VRBO
From $409 per night (USD)
VRBO
The Knotty Pine House
Bedrooms:
2
Bathrooms:
4
Sleeps:
12
Cozy and Modern Retreat in the Heart of St. Charles, MO Welcome to your perfect getaway! This charming and stylish home ...
From $409 per night (USD)
VRBO
From $188 per night (USD)
Expedia
Cozy Clark Suite in Frenchtown
Bedrooms:
1
Bathrooms:
1
Sleeps:
4
Welcome to your perfect getaway nestled in the heart of Frenchtown, Saint Charles! This spacious suite combines historic ...
From $188 per night (USD)
Expedia
From $311 per night (USD)
VRBO
Cottage on Main st- Low Cleaning Fee
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
MESSAGE FOR SHORT TERM DISCOUNT Welcome to your ideal Main Street getaway in the heart of Historic St. Charles! Where ...
From $311 per night (USD)
VRBO
From $312 per night (USD)
Expedia
Cottage on Historic Main Street- Low Cleaning fee
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
ON MAIN ST- MESSAGE FOR DISCOUNT ON SHORT STAY Enjoy walkable luxury in historic St. Charles! This updated 2BR, 1BA uni ...
From $312 per night (USD)
Expedia
From $207 per night (USD)
VRBO
Free Breakfast. Pool & Gym. Near Progress West Hospital!
Bedrooms:
1
Bathrooms:
1
Sleeps:
6
Enjoy a wonderful trip to O'Fallon, courtesy of our 1 Bedroom Suite! It's close to the Busch Conservation Area, Progress ...
From $207 per night (USD)
VRBO
From $233 per night (USD)
Expedia
King Suite. Free Breakfast. Pool & Gym. Your Next Trip!
Bedrooms:
1
Bathrooms:
1
Sleeps:
4
Enjoy a wonderful trip to O'Fallon, courtesy of our 1 Bedroom Suite! It's close to the Busch Conservation Area, Progress ...
From $233 per night (USD)
Expedia
From $723 per night (USD)
VRBO
Family Friendly Lake Front retreat with Lake Front Beach and Dock.
Bedrooms:
3
Bathrooms:
5
Sleeps:
10
Stay comfortably in our 5 bedroom 4400 sq ft Ranch home, 3.5 acre lake front estate in Lake St Louis. A short 2 min walk ...
From $723 per night (USD)
VRBO
From $173 per night (USD)
Expedia
Intimate Suite – Perfect for Date Nights-Fox Suite
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
The Fox Suite at the Divine Otter Hotel offers a stylish 1-bedroom escape with a futon, sleeping up to 3 guests. Enjoy u ...
From $173 per night (USD)
Expedia
From $205 per night (USD)
VRBO
Calming, Chic Space w/ Natural Light- Owl Suite
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
The Owl Suite at the Divine Otter Hotel offers a stylish 1-bedroom escape, sleeping up to 2 guests. Enjoy upscale furnis ...
From $205 per night (USD)
VRBO
From $182 per night (USD)
Expedia
Comfort Meets Style–Boutique Experience-Buck Suite
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
The Buck Suite at the Divine Otter Hotel offers a stylish 1-bedroom escape, sleeping up to 2 guests. Enjoy upscale furni ...
From $182 per night (USD)
Expedia
From $176 per night (USD)
VRBO
Modern Boutique Stay w/ Plush King Bed- Hare Suite
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
The Hare Suite at the Divine Otter Hotel offers a stylish 1-bedroom escape, sleeping up to 2 guests. Enjoy upscale furni ...
From $176 per night (USD)
VRBO
From $317 per night (USD)
Expedia
Dog-Friendly House by Main Street
Bedrooms:
1
Bathrooms:
2
Sleeps:
6
Welcome to your home away from home! This newly refurbished 2-bedroom, 1-bathroom house is ideally located just blocks f ...
From $317 per night (USD)
Expedia
From $259 per night (USD)
VRBO
Private Entry Basement Suite • Pond & Farm View • Pet Friendly • St Peters
Bedrooms:
1
Bathrooms:
1
Sleeps:
4
Enjoy a private, comfortable basement guest suite in our quiet, owner-occupied home. Ideal for visiting family, extended ...
From $259 per night (USD)
VRBO
From $326 per night (USD)
VRBO
Spacious Historic Townhouse - Character for All
Bedrooms:
2
Bathrooms:
2
Sleeps:
8
This charming spacious historic townhouse is a completely renovated century-old duplex, near Historic Old Town St. Charl ...
From $326 per night (USD)
VRBO
From $229 per night (USD)
VRBO
Downtown Boutique Comfort w/ Style- Otter Suite
Bedrooms:
1
Bathrooms:
2
Sleeps:
6
The Otter Suite at the Divine Otter Hotel offers a stylish 2-bedroom escape, sleeping up to 6 guests. Enjoy upscale furn ...
From $229 per night (USD)
VRBO
From $136 per night (USD)
VRBO
Sweet, Suburban Stay: Peaceful, Safe & Furnished
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
This newly built, fully furnished 1-bedroom unit offers modern comfort and a peaceful living experience on the third flo ...
From $136 per night (USD)
VRBO
From $273 per night (USD)
VRBO
Wentzville 3BR | Office, Gym & Theater
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Modern 3BR/2BA Wentzville Bungalow with Office, Gym & Home Theater Setup Welcome to your stylish home-away-from-home in ...
From $273 per night (USD)
VRBO
From $544 per night (USD)
VRBO
Countryside Lakefront Chalet
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Welcome to this charming country house in Lake Saint Louis. This beautiful 3.5 acre property features 3 cozy bedrooms - ...
From $544 per night (USD)
VRBO
From $192 per night (USD)
VRBO
Sweet, Surbarban Stay; Peaceful, safe and furnished
Bedrooms:
2
Bathrooms:
2
Sleeps:
4
Newly built in 2023, this furnished 2-bedroom, 2-bath in Lake Saint Louis offers peace and comfort with stylish décor, W ...
From $192 per night (USD)
VRBO
From $471 per night (USD)
Expedia
Family Friendly w/ Game Room in Quiet Neighborhood
Bedrooms:
3
Bathrooms:
5
Sleeps:
13
Spacious 5-bedroom smart home perfect for families & groups! Features blazing-fast Wi-Fi, a fully equipped chef`s kitche ...
From $471 per night (USD)
Expedia
From $229 per night (USD)
VRBO
Wentzville King Bed Walk to Downtown!
Bedrooms:
1
Bathrooms:
1
Sleeps:
4
This charming unit is a perfect blend of comfort and style. The bedroom features a luxurious king-size bed, a cozy sitti ...
From $229 per night (USD)
VRBO
From $214 per night (USD)
Expedia
Private Basement - Two King Beds and Hot Tub
Bedrooms:
1
Bathrooms:
1
Sleeps:
4
Welcome to our private and cozy basement retreat with a Hot Tub! Our beautifully furnished basement unit is perfect for ...
From $214 per night (USD)
Expedia
From $264 per night (USD)
VRBO
Two King and Two Twin Beds in the Heart of French Town
Bedrooms:
1
Bathrooms:
3
Sleeps:
6
The space Maison Champignon is a charming 3BR/1BA getaway with a warm French-Country feel, nestled in the heart of St. C ...
From $264 per night (USD)
VRBO
From $245 per night (USD)
Expedia
Adorable 2 King Bed Frenchtown Home
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
You are going to love this stylish and well decorated home in St Charles. Well Stocked with all the amenities you will n ...
From $245 per night (USD)
Expedia
From $296 per night (USD)
VRBO
Completely Renovated Home in St. Charles, Missouri
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Welcome to your perfect getaway in St. Charles, Mo! Come enjoy this newly renovated charming three-bedroom, two-bathroom ...
From $296 per night (USD)
VRBO
From $308 per night (USD)
Expedia
Charming Historic Retreat in Old Town St. Charles
Bedrooms:
2
Bathrooms:
1
Sleeps:
6
Experience the charm of Old Town St. Charles in this cozy and beautifully restored home. Just steps from local shops, di ...
From $308 per night (USD)
Expedia
From $1066 per night (USD)
VRBO
The Reunion House | St Charles 4BR Sleeps 14 Game Room Hot Tub | Mercer Stays
Bedrooms:
3
Bathrooms:
4
Sleeps:
14
Price improvement on 8-31-2026🎉 Welcome to The Reunion House by Mercer Stays 🏠 NEED MORE ROOM? BOOK THE BLOCK BY MER ...
From $1066 per night (USD)
VRBO
From $170 per night (USD)
Expedia
Cozy 1-bedroom bungalow in peaceful Saint Charles with AC
Bedrooms:
1
Bathrooms:
1
Sleeps:
4
Located in Saint Charles, enjoy what this 1-bedroom bungalow has to offer. This fantastic space features a cozy living r ...
From $170 per night (USD)
Expedia
From $272 per night (USD)
VRBO
3BR Retreat Near Historic Main Street-Low Cleaning-Sleeps 6
Bedrooms:
1
Bathrooms:
3
Sleeps:
6
Just 1.1 miles from Historic Main Street, Katy Trail, and Downtown St. Charles, this beautifully updated 3BR/1BA home pu ...
From $272 per night (USD)
VRBO
From $189 per night (USD)
Expedia
Enjoyable 1-bedroom house with AC in Historic Saint Charles
Bedrooms:
1
Bathrooms:
1
Sleeps:
4
Charming midterm rental in historic Frenchtown, St. Charles. Just minutes from Lindenwood University, a short drive to S ...
From $189 per night (USD)
Expedia
From $330 per night (USD)
VRBO
Riverwood Retreat | Main Street 2BR
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Welcome to Riverwood Retreat, a two-bedroom flat where warm wood tones, natural textures, and modern comfort meet the en ...
From $330 per night (USD)
VRBO
From $334 per night (USD)
Expedia
Retro Retreat - Pet-Friendly
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Stay steps from Main Street at The Retro Retreat, a pet-friendly 2-bedroom flat with playful 1980s style. Unwind with so ...
From $334 per night (USD)
Expedia
From $378 per night (USD)
VRBO
Luxury 2-Bedroom Apt , St. Charles Retreat Smart Home Comfort & Modern Elegance
Bedrooms:
2
Bathrooms:
2
Sleeps:
4
Welcome to Apartment B, a beautifully renovated, fully furnished SECOND-FLOOR apartment where historic character meets t ...
From $378 per night (USD)
VRBO
From $447 per night (USD)
Expedia
T Luxury Pool, Hot tub, Arcade Game Comfortable House
Bedrooms:
3
Bathrooms:
4
Sleeps:
10
Welcome to your luxury retreat! This stylish home blends modern comfort with unforgettable fun. Relax in the bright coas ...
From $447 per night (USD)
Expedia
From $409 per night (USD)
VRBO
Historic Craftsman • Hot Tub • Walk to Wineries • Katy Trail
Bedrooms:
1
Bathrooms:
2
Sleeps:
8
The Craftsman on Walnut is a recently renovated 100-year-old home located on historic Walnut Street in the heart of char ...
From $409 per night (USD)
VRBO
From $330 per night (USD)
Expedia
The Bourbon & Brass | Speakeasy-Inspired 2BDR
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Welcome to The Bourbon & Brass, a stylish 2-bedroom, 1-bath flat in the heart of St. Charles, perfect for up to 4 guests ...
From $330 per night (USD)
Expedia
From $350 per night (USD)
VRBO
Modern 2BR | Historic Entertainment District
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Historic brick and clean modern lines meet at The Brick & Beam, a two-bedroom flat near Historic Main Street St. Charles ...
From $350 per night (USD)
VRBO
From $298 per night (USD)
Expedia
The Global Getaway | World-Inspired 2-Bedroom Stay
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Welcome to The Global Getaway, a stylish 2-bedroom, 1-bath flat in the heart of St. Charles, perfect for up to 4 guests. ...
From $298 per night (USD)
Expedia
From $223 per night (USD)
VRBO
Newly Furnished St. Charles Getaway- B
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Welcome to your newly furnished home away from home in St. Charles! This comfortable retreat features two queen beds, a ...
From $223 per night (USD)
VRBO
From $331 per night (USD)
Expedia
Hearth & Harvest | Historic St. Charles 2BR
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Welcome to Hearth & Harvest, a two-bedroom St. Charles retreat inspired by the warmth of farmhouse gathering spaces. Nat ...
From $331 per night (USD)
Expedia
From $334 per night (USD)
VRBO
Salt & Serenity Coastal-Inspired 2-Bedroom
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Welcome to Salt & Serenity, a serene and inviting 2-bedroom, 1-bath retreat in the heart of St. Charles, Missouri, locat ...
From $334 per night (USD)
VRBO
From $243 per night (USD)
Expedia
NEW 3-bedroom house in gorgeous O'Fallon
Bedrooms:
1
Bathrooms:
3
Sleeps:
6
Make yourself at home in this 3-bedroom O'Fallon retreat. This welcoming house features three queen beds, offering plent ...
From $243 per night (USD)
Expedia
From $334 per night (USD)
VRBO
Driftwood Den | Boho 2BR | Dog-Friendly
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Welcome to The Driftwood Den, a relaxed two-bedroom retreat near Historic Main Street St. Charles. Woven accents, natura ...
From $334 per night (USD)
VRBO
From $346 per night (USD)
Expedia
Stylish 2BR Retreat - Concrete & Canopy
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Welcome to Concrete & Canopy, a modern and inviting 2-bedroom, 1-bath retreat in the heart of St. Charles, Missouri, loc ...
From $346 per night (USD)
Expedia
From $334 per night (USD)
VRBO
The Rustic Revival | Charming 2BR Retreat
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Cozy 2-bed, 1-bath rustic-modern apartment in St. Charles, MO entertainment district. Sleeps 4. Steps from restaurants, ...
From $334 per night (USD)
VRBO
From $138 per night (USD)
Expedia
Townhouse on Perry - Walk to Main Street
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Completely rehabbed 2 bedroom 1.5 bath Townhouse in the heart of old town Saint Charles with walking distance to Main St ...
From $138 per night (USD)
Expedia
From $358 per night (USD)
VRBO
Oma’s Haus - Walk to Main Street!
Bedrooms:
1
Bathrooms:
3
Sleeps:
8
Oma’s Haus is your home away from home. Great location - close to everything. This home was built in 1900 and has been r ...
From $358 per night (USD)
VRBO
From $330 per night (USD)
Expedia
The Oak & Aura Retreat
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Welcome to Oak & Aura, a two-bedroom retreat shaped by warm oak accents, soft textures, and light-filled interiors. The ...
From $330 per night (USD)
Expedia
From $325 per night (USD)
VRBO
Madison House 2 - Spacious 2BR Home Steps from Historic Downtown St. Charles
Bedrooms:
2
Bathrooms:
2
Sleeps:
8
Just steps from Historic Main Street in St. Charles, Madison House 2 is a spacious 2-bedroom townhome in the heart of Ol ...
From $325 per night (USD)
VRBO
From $305 per night (USD)
Expedia
Madison House 1 - Spacious 2BR Home Steps from Historic Downtown St. Charles
Bedrooms:
1
Bathrooms:
2
Sleeps:
8
This stylish townhome is the perfect home base for your getaway to historic Saint Charles. Just a short walk to vibrant ...
From $305 per night (USD)
Expedia
From $334 per night (USD)
VRBO
Elegant 2BR | St Charles Entertainment Area
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
Welcome to The Sterling Stay, a two-bedroom retreat near Historic Main Street St. Charles. Warm wood accents, clean fini ...
From $334 per night (USD)
VRBO
From $290 per night (USD)
Expedia
Walk to Wineries: Charming Retreat in Augusta!
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
Screened Porch & Dining | Central Location | Private Yard A storybook stay awaits at this vacation rental in the heart ...
From $290 per night (USD)
Expedia
From $273 per night (USD)
VRBO
Home Retreat -Cozy Neighborhood, 2 bedroom, 3 full baths, 4 guests
Bedrooms:
3
Bathrooms:
2
Sleeps:
4
Located in O'Fallon, enjoy what this 2-bedroom house has to offer. The charming home features two king beds and three ba ...
From $273 per night (USD)
VRBO
From $318 per night (USD)
Expedia
The Accessible Atom | Historic Main
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
The Accessible Atom near Historic Main Street Stay beside the brick-lined Historic Main Street district in this dog-fri ...
From $318 per night (USD)
Expedia
From $411 per night (USD)
VRBO
Historic Home w/ Hot Tub and Game Room in Augusta
Bedrooms:
4
Bathrooms:
4
Sleeps:
8
Game Room | Hot Tub | Near Wineries & Vineyards | 10 Mi to Dtwn Washington Experience the ideal blend of countryside ch ...
From $411 per night (USD)
VRBO
From $589 per night (USD)
VRBO
Exquisite 4 bed & 4 bath with POOL in Historic District near Main Street
Bedrooms:
4
Bathrooms:
4
Sleeps:
13
Welcome to Clark Manor—an exquisite historic retreat nestled in the heart of St. Charles, just steps from its charming a ...
From $589 per night (USD)
VRBO
From $1264 per night (USD)
VRBO
The Stadium by Mercer Stays | Private 2.2Acre Sports Estate for Teams & Families
Bedrooms:
3
Bathrooms:
4
Sleeps:
12
🏆 WELCOME TO THE STADIUM 🏟️ PRICE IMPROVEMENT 8/24/26! Built for being together. A Mercer Stays home. 🏟️ NEED MORE ...
From $1264 per night (USD)
VRBO
From $517 per night (USD)
VRBO
Hot Tub Gazebo, Fire Pit, Fenced Yard & Playset - 2 Kings, Sleeps 10
Bedrooms:
2
Bathrooms:
4
Sleeps:
10
Built with families and groups in mind, this home features a hot tub beneath a private covered gazebo, a fire pit, a fen ...
From $517 per night (USD)
VRBO
From $611 per night (USD)
VRBO
Spacious 5-bedroom house in serene O'Fallon with AC
Bedrooms:
2
Bathrooms:
5
Sleeps:
10
Nestled in O'Fallon, this beautiful house offers a serene retreat for guests seeking comfort and space. With five bedroo ...
From $611 per night (USD)
VRBO
From $253 per night (USD)
Expedia
Country Knoll 4/2 with 6 beds
Bedrooms:
2
Bathrooms:
4
Sleeps:
7
Make yourself at home in this 4-bedroom Saint Charles house. With three twin beds, one full bed, and a queen bed, there’ ...
From $253 per night (USD)
Expedia
From $388 per night (USD)
VRBO
Cambrook - 5 bedrm - 8 Beds 2 bathrooms
Bedrooms:
2
Bathrooms:
5
Sleeps:
10
Located in Saint Charles, this house is a dream. With five comfortable bedrooms, including a queen, a full, and four twi ...
From $388 per night (USD)
VRBO
From $223 per night (USD)
Expedia
Barrington 4-bedroom 6 beds
Bedrooms:
2
Bathrooms:
4
Sleeps:
7
Located in St. Peters, this gorgeous house offers plenty of space with four queen bedrooms, perfect for families or grou ...
From $223 per night (USD)
Expedia
From $270 per night (USD)
VRBO
Tulip - 8 beds, 2 bath, 5 bedrms- sleeps 13+
Bedrooms:
2
Bathrooms:
4
Sleeps:
11
8 BEDS, 5 BEDROOMS, 2 BATH ...... Corporate and business long term stays available. This spacious cozy home is just what ...
From $270 per night (USD)
VRBO
From $227 per night (USD)
Expedia
Sharon B - Sleeps 12 - 4 bedrm - 8 Bed
Bedrooms:
1
Bathrooms:
4
Sleeps:
12
7 BEDS - 3 BEDROOMS - SLEEPS 11....Contractors, Business Porfessionals, and Large Groups. This is the ideal place for yo ...
From $227 per night (USD)
Expedia
From $284 per night (USD)
VRBO
Shagbark - 7 Beds - 4 Baths
Bedrooms:
4
Bathrooms:
4
Sleeps:
9
7 Bed, 4 Bath home is designed for displaced families due to house fires, water leaks, and other home catastrophes, as w ...
From $284 per night (USD)
VRBO
From $325 per night (USD)
Expedia
Gran Lin - 5 bedroom - 8 beds
Bedrooms:
3
Bathrooms:
5
Sleeps:
10
This Saint Charles house boasts 5 inviting bedrooms, including 2 queen beds and 3 twin beds, perfect for families or gro ...
From $325 per night (USD)
Expedia
From $225 per night (USD)
VRBO
Charming 3-bedroom house in St. Peters with AC and comfort
Bedrooms:
1
Bathrooms:
3
Sleeps:
6
Get ready to relax in this 3-bedroom house in St. Peters. Each bedroom features a comfortable queen bed, perfect for a r ...
From $225 per night (USD)
VRBO
From $525 per night (USD)
VRBO
T Luxury Pool, Hot-tub and Arcade Game Room House
Bedrooms:
2
Bathrooms:
4
Sleeps:
12
Welcome to your luxurious retreat! This spacious *4-bedroom, 2-bathroom home* is designed to provide you with unmatched ...
From $525 per night (USD)
VRBO

Search Your Destination Now!

Saint Charles Area Rentals

Rental Rates ($USD weekly)

Guests

Check Rates & Availability:

Results: 210 Rentals